師資陣容
教師介紹 醫學系教師 預備教師  
 

 

教師姓名
蔡怡汝
專任教授兼所長
(office)29053412,29053495;(Lab)29053901
E-mail
065735@mail.fju.edu.tw
學 經 歷
1. 國立臺灣大學醫學院解剖學暨細胞生物學研究所博士
2. 輔仁大學醫學教育中心主任
3. 輔仁大學醫學系副教授
4. 輔仁大學醫學系助理教授
5. 國立臺灣大學醫學院醫學系解剖學暨細胞生物學科助教
1. 神經解剖學
2. 周邊神經損傷研究
3. 疼痛生物學
研究領域
1. 周邊神經病變疼痛的機轉探討及治療
2. 重症疾病引發神經病變的機轉探討
 
 
著作
A. 學術期刊論文

1. Te-Wei Ho, Yi-Ju Tsai, Sheng-Yuan Ruan, Chun-Ta Huang*, Feipei Lai, Chong-Jen Yu. The HINT Study Group (2014) In-hospital and one-year mortality and their predictors in patients hospitalized for first-ever chronic obstructive pulmonary disease exacerbations: a nationwide population-based study. PLoS One 9(12), e114866.
 
2. Jiann-Horng Yeh, Chun-Ta Huang*, Chia-Hsiung Liu, Sheng-Yuan Ruan, Yi-Ju Tsai, Ying-Chun Chien, Ching-Yao Yang, Chun-Kai Huang, Chia-Lin Hsu, Lu-Cheng Kuo, Pei-Lin Lee, Shih-Chi Ku, Ping-Hung Kuo, Chong-Jen Yu. The HINT Study Group (2014) Cautious application of pleural N-terminal pro-B-type natriuretic peptide in diagnosis of congestive heart failure pleural effusions among critically ill patients. PLoS One 9(12), e115301.
 
3. Chun-Ta Huang, Rayleigh Ping-Ying Chiang, Chih-Li Chen, Yi-Ju Tsai*. (2014) Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion. Sleep 37(9), 1513-1523. 
 
4. Chun-Ta Huang*, Hsien-Ho Lin, Sheng-Yuan Ruan, Meng-Sui Lee, Yi-Ju Tsai, Chong-Jen Yu. (2014) Efficacy and adverse events of high frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis. Critical Care 18(3), R102.
 
5. Chun-Ta Huang, Li-Na Lee, Chao-Chi Ho, Chin-Chung Shu, Sheng-Yuan Ruan, Yi-Ju Tsai, Jann-Yuan Wang*, Chong-Jen Yu. (2014) High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis. Journal of Infection 68(5), 440-447.
 
6. Chun-Ta Huang*, Yi-Ju Tsai, Jou-Wei Lin, Sheng-Yuan Ruan, Huey-Dong Wu, Chong-Jen Yu .(2014) Application of heart-rate variability in patients undergoing weaning from mechanical ventilation. Critical Care 18(1), R21.
 
7. Shih-Ping Hung, Ming-Jen Sheu, Ming-Chieh Ma, Jui-Ting Hu, Ya-Yun Sun, Chin-Cheng Lee, Yuan-Chiang Chung, Yi-Ju Tsai, Jing-Yuan Wang, Chih-Li Chen*. (2014) Runx1-deficient afferents impair visceral nociception, exacerbating dextran sodium sulfate-induced colitis. Brain Behavior and Immunity 35, 96-106.
 
8. Chun-Ta Huang, Yi-Ju Tsai, Pi-Ru Tsai, Wen-Je Ko*. (2013) Extracorporeal membrane oxygenation resuscitation in adult patients with refractory septic shock. Journal of Thoracic and Cardiovascular Surgery 146(5), 1041-1046. 
 
9. Shih-Chang Lin, Yi-Ju Tsai, Chun-Ta Huang*, Yao-Wen Kuo, Sheng-Yuan Ruan, Yu-Chung Chuang, Chong-Jen Yu. (2013) Prognostic value of plasma N-terminal pro B-type natriuretic peptide levels in pneumonia patients requiring intensive care unit admission. Respirology 18(6), 933-941.
 
10.Hsin-Ying Wang, Yi-Ju Tsai, Seu-Hwa Chen, Chi-Te Lin, June-Horng Lue*. (2013) Lysophosphatidylcholine causes neuropathic pain via the increase of neuronal nitric oxide synthase in the dorsal root ganglion and cuneate nucleus. Pharmacology Biochemistry and Behavior 106, 47-56.
 
11. Yi-Ju Tsai, Kannan Ramar, Yao-Jen Liang, Po-Han Chiu, Nelson Powell, Chao-Yun Chi, Tzu-Chen Lung, Wesley Wen-Yang Lin, Po-Jung Tseng, Ming-Ying Wu, Kuan-Chiao Chien, Edward M. Weaver, Fei-Peng Lee, Chia-Mo Lin, Kuang-Chao Chen, Rayleigh Ping-Ying Chiang*. (2013) Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome. Sleep Medicine Reviews 17(2), 161-168. 
 
12. Rayleigh Ping-Ying Chiang, Chun-Ta Huang, Yi-Ju Tsai*. (2013) Melatonin reduces median nerve injury-induced mechanical hypersensitivity via inhibition of microglial p38 mitogen-activated protein kinase activation in rat cuneate nucleus. Journal of Pineal Research 54(2), 232-244.  
 
13.Chun-Ta Huang, Sheng-Yuan Ruan, Wei-Yu Liao, Yao-Wen Kuo, Chi-Ying Lin, Yi-Ju Tsai, Chao-Chi Ho*, Chong-Jen Yu. (2012) Risk factors of pneumothorax after endobronchial ultrasound-guided tansbronchial biopsy for peripheral lung lesions. PLoS One 7(11), e49125. 
 
14. Chun-Ta Huang, Yi-Ju Tsai, Wei-Yu Liao, Pei-Chen Wu, Chao-Chi Ho*, Chong-Jen Yu, Pan-Chyr Yang. (2012) Endobronchial ultrasound-guided transbronchial biopsy of peripheral pulmonary lesions: how many specimens are necessary? Respiration 84(2), 128-134. 
 
15. Seu-Hwa Chen, Yi-Ju Tsai, Chi-Te Lin, Hsin-Ying Wang, Shin-Fang Li, June-Horng Lue*. (2012) Changes in GABA and GABAB receptor expressions are involved in neuropathy in the rat cuneate nucleus following median nerve transection. Synapse 66(6), 561-572.  
 
16. Chun-Ta Huang, Yi-Ju Tsai, Huey-Dong Wu, Jann-Yuan Wang*, Chong-Jen Yu, Li-Na Lee, Pan-Chyr Yang. (2012) Impact of non-tuberculous mycobacteria on pulmonary function decline in chronic obstructive pulmonary disease. International Journal of Tuberculosis and Lung Disease 16(4), 539-545. 
 
17. Yi-Ju Tsai*, Chun-Ta Huang, Shih-Chang Lin, Jiann-Horng Yeh. (2012) Effects of regional and whole-body hypothermic treatment before and after median nerve injury on neuropathic pain and glial activation in rat cuneate nucleus. Anesthesiology 116(2), 415-431.  
 
18. Seu-Hwa Chen, Yi-Ju Tsai, Hsin-Ying Wang, Chi-Te Lin, Shin-Fang Li, June-Horng Lue*. (2012) Decreases of glycine receptor expression induced by median nerve injury in the rat cuneate nucleus contribute to NPY release and c-Fos expression. Life Sciences 90(7-8), 278-288. 
 
19. Hsin-Ying Wang, Yi-Ju Tsai, Seu-Hwa Chen, Chi-Te Lin, June-Horng Lue*. (2012) Nitric oxide implicates c-Fos expression in the cuneate nucleus following electrical stimulation of the transected median nerve. Neurochemical Research 37(1), 84-95.
 
 
20. Chi-Te Lin, Yi-Ju Tsai, Hsin-Ying Wang, Seu-Hwa Chen, Tzu-Yu Lin, June-Horng Lue*. (2012) Pre-emptive treatment of lidocaine attenuates neuropathic pain and reduces pain-related biochemical markers in the rat cuneate nucleus in median nerve chronic constriction injury model. Anesthesiology Research and Practice 2012, 1-9. 
 
21. Shih-Chang Lin, Jiann-Horng Yeh, Chih-Li Chen, Shiu-Huey Chou, Yi-Ju Tsai*. (2011) Effects of local lidocaine treatment before and after median nerve injury on mechanical hypersensitivity and microglia activation in rat cuneate nucleus. European Journal of Pain 15(4), 359-367. 
 
22. Yuan-Chiang Chung, Yi-Ju Tsai, Ting-Ying Shiu, Ya-Yun Sun, Pin-Fang Wang, Chih-Li Chen*. (2011) Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expression Patterns 11(1-2), 84-92. 
 
23. Chun-Ta Huang, Yi-Ju Tsai, Jun-Yu Fan, Shih-Chi Ku*, Chong-Jen Yu. (2010) Cryptococcosis and tuberculosis co-infection at a university hospital in Taiwan, 1993-2006. Infection 38(5), 373-379. 
 
24. Chi-Te Lin, Yi-Ju Tsai, Seu-Hwa Chen, Hsin-Ying Wang, Lung-Huang Lin, June-Horng Lue*. (2010) Early expression of injury-induced neuropeptide Y in primary sensory neurons and the cuneate nucleus in diabetic rats with median nerve transection. Journal of Chemical Neuroanatomy 40(2), 102-111. 
 
25.Ming-Tzer Lin, Yi-Ju Tsai, Chun-Ta Huang*. (2010) Right-sided cardiophrenic mass in an older woman. American Family Physician 82(8), 971-972. 
 
26. Chun-Ta Huang, Rouh-Fang Yen, Mei-Fang Cheng, Ya-Chieh Hsu, Pin-Fei Wei, Yi-Ju Tsai, Meng-Feng Tsai, Jin-Yuan Shih*, Chih-Hsin Yang, Pan-Chyr Yang. (2010) Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma. Medical Oncology 27(1), 9-15. 
 
27. Jiann-Jy Chen, June-Horng Lue, Lung-Huang Lin, Chun-Ta Huang, Rayleigh Ping-Ying Chiang, Chih-Li Chen, Yi-Ju Tsai*. (2010) Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury. Pain 148(1), 158-166. 
 
28. Chun-Ta Huang, Yi-Ju Tsai, Chin-Chung Shu, Yung-Chao Lei, Jann-Yuan Wang*, Chong-Jen Yu, Li-Na Lee, Pan-Chyr Yang, The TAMI Group. (2009) Clinical significance of isolation of nontuberculous mycobacteria in pulmonary tuberculosis patients. Respiratory Medicine 103(10), 1484-1491. 
 
29. Yi-Ju Tsai, Chi-Te Lin, Chun-Ta Huang, Hsin-Ying Wang, Lu-Tai Tien, Seu-Hwa Chen, June-Horng Lue*. (2009) Neuropeptide Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median nerve injury. Journal of Neurotrauma 26(9), 1609-1621. 
 
30. Chi-Te Lin, Hsin-Ying Wang, Yi-Ju Tsai, Chun-Ta Huang, Seu-Hwa Chen, June-Horng Lue*. (2009) Pre-treatment with lidocaine suppresses ectopic discharges and attenuates neuropeptide Y and c-Fos expressions in the rat cuneate nucleus following median nerve transection. Journal of Chemical Neuroanatomy 38(1), 47-56. 
 
31. Chun-Ta Huang, Chao-Chi Ho*, Yi-Ju Tsai, Chong-Jen Yu, Pan-Chyr Yang. (2009) Factors influencing visibility and diagnostic yield of transbronchial biopsy using endobronchial ultrasound in peripheral pulmonary lesions. Respirology 14(6), 859-864. 
 
32. Chun-Ta Huang, Ping-Hung Kuo*, Ming Yao, Yi-Ju Tsai, Pan-Chyr Yang. (2008) Pleural effusion heralds acute leukemic transformation of chronic myelomonocytic leukemia. Southern Medical Journal 101(12), 1279-1280. 
 
33. Jiann-Horng Yeh, June-Horng Lue, Hsin-Ying Wang, Chun-Ta Huang, Yi-Ju Tsai*. (2008) Synaptic relationships between induced neuropeptide Y-like immunoreactive terminals and cuneothalamic projection neurons in the rat cuneate nucleus following median nerve transection. Journal of Chemical Neuroanatomy 36(1), 27-32. 
 
34. Chun-Ta Huang, Yih-Leong Chang, Yi-Ju Tsai, Shih-Chi Ku*, Chong-Jen Yu. (2008) Cryptogenic organizing pneumonia mimicking community-acquired pneumonia with acute respiratory failure: a case report. Thoracic Medicine 23(4), 297-303. 
 
35. Chun-Ta Huang, Chao-Chi Ho*, Yi-Ju Tsai, Pan-Chyr Yang. (2008) The first case report of dental floss pick-related injury presenting with massive hemoptysis: a case report. Journal of Medical Case Reports 2(78), 1-5. 
 
36. Yi-Ju Tsai, Chi-Te Lin, June-Horng Lue*. (2007) Characterization of the induced neuropeptide Y-like immunoreactivity in primary sensory neurons following complete median nerve transection. Journal of Neurotrauma 24(12), 1878-1888. 
 
37. Yi-Ju Tsai, Ming-Chieh Ma, Chih-Li Chen, Han-Sun Chiang, Chun-Ta Huang, Yuan-Chan Chung*. (2006) Stem cells in the management of myocardial infarctions. Fu-Jen Journal of Medicine 4(4), 13-19. 
 
38. Ming-Chieh Ma, Shiu-Huey Chou, Yi-Ju Tsai, Han-Sun Chiang, Jiann-Jy Chen*. (2006) Stem cell-mediated neurogenesis and neuroprotection. Fu-Jen Journal of Medicine 4(4), 1-11. 
 
39. Chih-Li Chen, Yu-Tzu Huang, Yi-Ju Tsai, Chin-Cheng Lee, Shih-Yun Huang, Shiou Chang*. (2006) Mobilization of hematopoietic stem cells. Fu-Jen Journal of Medicine 4(4), 31-39. 
 
40. Yi-Ju Tsai, Sok-Man Leong, An-Shiou Day, Chen-Yuan Wen, Jeng-Yung Shieh, June-Horng Lue*. (2004) A time course analysis of the changes in neuropeptide Y immunoreactivity in the rat cuneate nucleus following median nerve transection. Neuroscience Research 48(4), 369-377. 
 
41. June-Horng Lue*, Sok-Man Leong, An-Shiou Day, Yi-Ju Tsai, Jeng-Yung Shieh, Chen-Yuan Wen. (2002) Changes in c-Fos protein expression in the rat cuneate nucleus after electric stimulation of the transected median nerve. Journal of Neurotrauma 19(7), 897-907. 
B. 學術會議論文
1. Rayleigh Ping-Ying Chiang, Yi-Ju Tsai. Abnormal afferent nerve endings in the uvulae of patients with obstructive sleep apnea. The 24th Annual Meeting of the Associated Professional Sleep Societies, LLC, San Antonio, Texas, U.S.A., 2010.
 
2. Chun-Ta Huang, Yi-Ju Tsai. Amelioration of peripheral neuropathy by implantation of neural stem cells in an animal model. The 2nd Pan Pacific Symposium on Stem Cells Research, Taichung, Taiwan, 2009. (Best Poster Award)
 
3. Yi-Tien Li, Shih-Chi Huang, Wan-Ting Liao, Chih-Li Chen, Chun-Ta Huang, Yi-Ju Tsai. Bone marrow mesenchymal stem cells reduce neuropathic pain behaviors in a rat model of chronic neuropathy. The 24th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2009.
 
4. Yi-Ju Tsai, Ming-Tai Yu, Chih-Li Chen, Chun-Ta Huang, Yu-Tzu Huang, June-Horng Lue. Changes in interleukin-1β and astrocytes expression in rat median nerve chronic constriction injury model. The 23th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2008.
 
5. Yi-Ju Tsai, Chi-Te Lin, Seu-Hwa Chen, Hsin-Ying Wang, June-Horng Lue. Effects of median nerve constriction injury along with reagents treatment on the changes in the activation of astrocytes in the rat cuneate nucleus. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2007.
 
6. Yi-Ju Tsai, Seu-Hwa Chen, Chi-Te Lin, Hsin-Ying Wang, June-Horng Lue. The interaction of neuropeptide Y with c-Fos protein expression in the rat cuneate nucleus with transected median nerve. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2007.
 
7. Chi-Te Lin, Yi-Ju Tsai, Hsin-Ying Wang, Mimg-Chuan Chang, Seu-Hwa Chen, June-Horng Lue. Pre-emptive treatment of lidocaine reduced nociceptive neuronal marker and relieved neuropathic pain behavior in median nerve injured rats. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2007.
 
8. Hsin-Ying Wang, Chi-Te Lin, Mimg-Chuan Chang, Yi-Ju Tsai, Seu-Hwa Chen, June-Horng Lue. The changes of brain-derived neurotrophic factors and Trk B in primary sensory neurons after median nerve transection. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwain, 2007.
 
9. Yi-Ju Tsai, Chi-Te Lin, Seu-Hwa Chen, June-Horng Lue. Characterization of the induced neuropeptide Y-like immunoreactivity in dorsal root ganglion neurons following complete median nerve transection. The Twentieth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2005.
 
10. Chi-Te Lin, Yi-Ju Tsai, Seu-Hwa Chen, June-Horng Lue. Effect of pre-emptive lidocaine treatment on neuropathic pain and cuneate neuron Fos protein expression in chronic median constriction rat. The Twentieth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2005
.
 
11. Yi-Ju Tsai, Chen-Yuan Wen, Jeng-Yung Shieh, June-Horng Lue. Synaptic relationships between induced neuropeptide Y-immunoreactive terminals and cuneothalamic projection neurons in the rat cuneate nucleus following median nerve transection. The Nineteenth Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2004.

 

 
近五年來研究計劃
1. 科技部計畫: 以大鼠敗血症模型探討重症神經病變之神經組織變化與相關機轉 (三年期計畫) (103.08-106.07)
2. 國科會計畫: 以創傷性腦損傷的研究實例配合發展小型動物正子斷層攝影的定量追蹤技術 (三年期計畫,共同主持人) (102.08-105.07)
3. 國科會計畫: 在大白鼠神經病變模式中Docosahexaenoic acid對於神經保護作用之研究 (101.08-102.07)
4. 國科會計畫: 探討睡眠剝奪於大白鼠軀體與內臟疼痛造成之影響 (三年期計畫) (98.08-101.07)
5. 國科會計畫: 正中神經損傷配合局部或全身低體溫處理神經膠細胞以及發炎前驅物對大白鼠楔狀神經核及其背根神經節表現變化的影響(96.08-98.07)
6. 行政院衛生署立桃園醫院: 幹細胞在心血管與神經退化疾病治療之應用 (整合型計畫) (95.05-95.12)
7. 國科會計畫: 正中神經損傷配合藥劑處理對大白鼠楔狀神經核神經膠細胞表現變化的影響 (95.05-96.04))
其他合作案包括與新光醫院及國泰醫院之合作計畫案多件
 
研究室簡介
在一般正常狀況下,疼痛感覺被視為生物體受到外界傷害性刺激所引起之警訊,可以避免更進一步的刺激因而危害到個體的存活,所作的有利於生物體的防護措施。但是在具有神經損傷的患者身上,其受傷神經所支配的區域發展出對輕觸覺刺激產生異常的觸摸痛,對於這種不正常的疼痛感覺稱之為「神經病變性疼痛(neuropathic pain)」。目前臨床上仍然沒有發現有效的治療方式,是因為對於此種疼痛產生的機轉不甚清楚,所以本實驗室利用各種研究方法,包括免疫化學染色、電生理、電子顯微鏡觀察、生化技術,致力於探討神經病變性疼痛的產生機轉。
                                                                                                                                                   

 
 
 
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